Centrality of drug targets in protein networks.

We measured differences between Phase4 and all targets after degree ‘normalization’ of the nodes’ topological coefficient [ log ( degree*topological coefficient ), Table 5 ] and observed that this combined parameter was markedly lower (significantly or near significance) for Phase4 enzymes in networks where their degree but not their topological coefficient had been significantly lower than that of other enzymes (String0.9, Reactome), confirming that Phase4 enzymes broadly exhibit lower topological coefficient than other target enzymes relative to the extent of their connections after this degree ‘normalization’.

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