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Adverse events related to bystander naloxone administration in cases of suspected opioid overdose in British Columbia: An observational study.

PLoS One · 2021 · PMC8555799 · PMID 34714854

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an increasing trendno p-value reported
Correlates of experiencing moderate or severe withdrawal symptoms with naloxone administration In the multivariable logistic regression model ( Table 3 ), there was an increasing trend in the odds of experiencing moderate or severe withdrawal associated with increasing ampoules of naloxone administered compared to those who had received one ampoule of naloxone (AOR = 1.29; 95% CI: 0.89–1.88 for two ampoules, AOR = 1.64; 95% CI: 1.08–2.48 for three ampoules, and AOR = 2.19; 95% CI: 1.32–3.62 for four or more ampoules).

also in 63,971 other papers

a decreasing trendno p-value reported
We identified a decreasing trend in the likelihood of moderate or severe withdrawal over the study period. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2021 Jul 19; Accepted 2021 Oct 12; Collection date 2021.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.