Natriuretic peptides are neuroprotective on in vitro models of PD and promote dopaminergic differentiation of hiPSCs-derived neurons via the Wnt/β-catenin signaling.

Moreover, at both times examined, highly significant increases in the expression levels of the DA neuron markers tyrosine hydroxylase (TH) and nuclear receptor-related 1 protein (Nurr1) as well as of the PD-related survival factor involved in neuroprotection DJ-1, have been recorded under treatments with all the three NPs (Fig. 1C, E ).

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