Dynamic interactions and Ca²⁺-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding.

We next tested the effect of different S100B concentrations (0.5, 1, 5, 10, and 30 μM) with 0.5 μM TauO, and observed a decreasing trend in TauO seeding activity, which was significant at the higher tested concentrations (Supplementary Fig. 19 ).

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