Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism.

We noted highly significant associations between the ratio of oxidative to reductive metabolites of phenylalanine (phenylacetylglutamine to PLA ratio), tyrosine (p-cresol glucuronide or sulfate to 3-(4-hydroxyphenyl)lactate), and tryptophan (indole acetate to ILA ratio) and EDSS scores, suggesting that a shift in reductive versus oxidative metabolism of AAA may be related to disability ( Figure 2 F).

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