A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA.

bins 53–153 or positions 5,300–15,400) show highly significant increases in mutation frequency across their respective genomic coordinates (minor arc: G→A slope = 8.24 ± 3.06 × 10 –8 , P = 0.007; T→C slope = 1.08 ± 0.35 × 10 –8 , P = 0.002; major arc: G→A slope = 7.42 ± 0.75 × 10 –8 , P = 5.35 × 10 –23 , T→C slope = 1.23 ± 0.10 ± 10 –8 , P = 1.33 × 10 –35 ).

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