Postpartum breast cancer has a distinct molecular profile that predicts poor outcomes.

Nat Commun · 2021 · PMC8566602 · PMID 34732713

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0.0011

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0.0011

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highly significantp = 0.0011actually significant

Although no parity history was available on these publicly available cases, upon applying our PPBC gene signature to this YWBC cohort ( n = 311 patients with both ER+ and ER− disease) we observed a highly significant decrease in 15-year overall survival in breast cancer patients with a PPBC Hi signature score (HR 2.134, p = 0.0011) compared with those with a low score (PPBC Lo, Fig. 5f ).

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