The integrin signaling pathway plays a role in fibrosis associated with human diseases and has a possible relationship to the CCKR and EFG receptor pathways (highly significant in both adults and children, Table S14 ) associated with fibrosis. 9 , 10 These differences in pathways relevant to HDLI and IPF, along with highly replicated enrichment of transcriptomes in the lung tissues of humans and rats exposed to PHMG (Figure 4C ), imply that the potential mechanisms related to HDLI may differ between IPF and other types of pulmonary fibrosis.
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Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury.
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