Appelt et al [ 36 ] described, in a predictive model study, a highly significant dose-response relationship for pCR after neoadjuant external-beam radiation therapy and brachytherapy in locally advanced rectal cancer for tumor dose levels in the range of 50.4-70 Gy.
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Neoadjuvant radiotherapy dose escalation for locally advanced rectal cancers in the new era of radiotherapy: A review of literature.
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