Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake.

Nat Commun · 2021 · PMC8571362 · PMID 34741066

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

highly significantno p-value reported

Recently, inclisiran, an siRNA targeting PCSK9 in individuals on maximally tolerated statin doses 46 led to a persistent, highly significant lowering of LDLc in treated individuals relative to placebo in a phase 3 study 47 , introducing siRNAs as an attractive therapeutic modality for lipid-lowering therapies.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.