One extraction tool for in vitro-in vivo extrapolation? SPME-based metabolomics of in vitro 2D, 3D, and in vivo mouse melanoma models.

J Pharm Anal · 2021 · PMC8572711 · PMID 34765281

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an increasing trendno p-value reported

Levels were stable throughout the tested time points for histidine and glutamic acid in the in vitro 2D cell culture, while an increasing trend over time was observed in in vitro 3D and in vivo models.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

One extraction tool for &lt;i&gt;in vitro-in vivo&lt;/i&gt; extrapolation? SPME-based metabolomics of &lt;i&gt;in vitro&lt;/i&gt; 2D, 3D, and &lt;i&gt;in vivo&lt;/i&gt; mouse melanoma models.

The sentences

One extraction tool for <i>in vitro-in vivo</i> extrapolation? SPME-based metabolomics of <i>in vitro</i> 2D, 3D, and <i>in vivo</i> mouse melanoma models.