Evolutionary coupling-inspired engineering of alcohol dehydrogenase reveals the influence of distant sites on its catalytic efficiency for stereospecific synthesis of chiral alcohols.

Comput Struct Biotechnol J · 2021 · PMC8572861 · PMID 34815831

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highly significantno p-value reported

This result obtained from mutations at distant sites is highly significant, especially compared with the previous work on structure-based rational design at the enzyme catalytic pocket [4] .

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