highly significantP < 0.001
In fact, the 3‐microRNA signature was consistently deregulated in a meta‐analysis performed on 15 different human and mouse datasets and revealed a highly significant pooled effect ( z = 5.33, P < 0.001) and standardized mean difference of 1.44 [lower interval: 0.91, upper interval: 1.98] (Fig 5I ).