Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8⁺ T Cell Functionality: An Alternative Viral Adaptation Strategy.

As a formal comparison of the TCR repertoires, TCR clonality (measure of the proportion of unique clonotypes of the total repertoire) was examined but there was no difference between the NAE and AE peptide activated CD8 + T cells for the epitopes tested in the chronic HIV-infected subjects and no difference in clonality between chronic and acute HIV-infected subjects ( Figure S2 ; although there was a slight trend for higher clonality in chronic HIV infection, p=0.13).

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