Recombinant Avian β-Defensin Produced by Food-Grade Lactococcus as a Novel and Potent Immunological Enhancer Adjuvant for Avian Vaccine.

Compared with the wild bacteria control group, negative blank control group, and PBS control group, the positive control group stimulated by LPS or 2′, 3′-cGAMP has differences extremely significant ( P < 0.0001; Fig. 2 A); the recombinant β-defensin rAvBD1-2–6-13 was also extremely significantly higher than the wild bacteria control group, negative blank control group, and PBS control group ( P < 0.0001; Fig. 2 A).

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P < 0.01 was considered highly significant, P < 0.001 was considered very highly significant, and P < 0.0001 was considered extremely highly significant.

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