The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

However, when we performed mediation analysis, conditioning on the expression of TOP2B , the association between CX-5461 IC 50 and MYCN expression was lost ( P = 0.8), but TOP2B remained highly significant ( P = 2.7 × 10 −4 ), suggesting that the association between MYCN and CX-5461 IC 50 was mediated through MYCN ’s effect on TOP2B expression.

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