Barely Significant
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PCSK9 Activity Is Potentiated Through HDL Binding.

Circ Res · 2021 · PMC8579991 · PMID 34601896

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highly significantno p-value reported
Methods and Results: Comparing lipoprotein and apolipoprotein profiles by nuclear magnetic resonance spectroscopy and targeted mass spectrometry measurements with PCSK9 levels in the community-based Bruneck study (n=656) revealed a positive association of plasma PCSK9 with small HDL, alongside a highly significant positive correlation between plasma levels of PCSK9 and apolipoprotein C3 (apoC3), an inhibitor of lipoprotein lipase.

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