A brain proteomic signature of incipient Alzheimer's disease in young <i>APOE</i> ε4 carriers identifies novel drug targets.

Sci Adv · 2021 · PMC8580310 · PMID 34757788

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0530

boldest claim

The sentences

highly significantP < 0.00001actually significant

The YAPS, BLSA, and ROS proteomic signatures, including 86, 254, and 244 significantly altered proteins, respectively, share 25 proteins, and this intersection, defined as the incipient AD proteomic signature, is highly significant (SuperExactTest, P < 0.00001).

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marginally significantP = 0.053so close (0.05 < p ≤ 0.1)

STAT3 levels (marginally significant) were higher in AD relative to CN ( P = 0.053) ( Fig. 5B ).

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