The p -values are indicated as follows: ns: not significant; * p < 0.05: significant; ** p < 0.01: highly significant. 3 Results 3.1 Preparation and characterization of SARS-CoV-2 rS1 protein In this study, the BacMos system was employed to produce a recombinant SARS-CoV-2 S1 protein for vaccine development.
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Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice.
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