Functional screen of inflammatory bowel disease genes reveals key epithelial functions.

Genome Med · 2021 · PMC8582123 · PMID 34758847

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Extending our analyses to the remaining genes within Cluster 1 also identified highly significant enrichments of IRF1, IRF7, and STAT1::STAT2 sites within the promoters of the HITS from ZFP36L1, IRF1, GIGYF1, OTUD3, and AIRE expressing lines, and of NFkB sites within the promoters of the HITS from PITX1 expressing lines, but no detectable enrichment of such sites for FOS or FOXO1 HITS (Additional file 1 : Table S6).

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