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High-Molecular-Weight Hyaluronic Acid Inhibits IL-1β-Induced Synovial Inflammation and Macrophage Polarization through the GRP78-NF-κB Signaling Pathway.

Int J Mol Sci · 2021 · PMC8584972 · PMID 34769349

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an increasing trendno p-value reported
In this study, we first found that the GRP78 in synovial cells showed an increasing trend in an IL-1β-induced mimic OA microenvironment.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.