Near-infrared light triggered multi-hit therapeutic nanosystem for tumor specific photothermal effect amplified signal pathway regulation and ferroptosis.

* p < 0.05 and ** p < 0.01 were considered to be significant and highly significant differences, respectively. 3 Results and discussion 3.1 Characterization of sPP copolymer and 17-DMAG-HMPB@sPP@HA NPs The thermotropic phase transition material sPP copolymer, which consisted of star-PEG2000 and terminal PCL1000 segment, was successfully synthesized ( Fig. 1 a).

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