Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to <i>para</i>-Quinone Methides.

Molecules · 2021 · PMC8588318 · PMID 34770741

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may be significantno p-value reported

The use of six alternative solvents was investigated (PhMe, CH 2 Cl 2 , CHCl 3 , THF, 1,4-dioxane and DMF), (see the Supporting Information for details) however, only the use of DMF provided any conversion to the product, indicating that solvent polarity may be significant for the success of this transformation.

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