As expected, in both control and cahErbb2-treated hiPSC-CMs, Meki or Erki treatment resulted in a dose-dependent decrease in EdU incorporation and a dose-dependent increase or an increasing trend in apoptotic events ( Figure 5—figure supplement 1 ).
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Human Erbb2-induced Erk activity robustly stimulates cycling and functional remodeling of rat and human cardiomyocytes.
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