RNA-seq driven expression and enrichment analysis to investigate CVD genes with associated phenotypes among high-risk heart failure patients.

Some of these highly significant genes have already been reported in multiple CVDs (APOD, PIGR, CELSR1, COBLL1, FCRL5, TEAD2, ABCA6, COL4A3, CYP4F2, FMOD, GNG8, IGF2R, PEG10, RAPGEF3, RASGRF1, SCARNA17, TCF4), while some genes (ADAM29, ARHGAP44, CD200, CLEC17A, CLNK, CNTNAP1, CNTNAP2, CTC-454I21.3, DMD, FAM129C, FAM3C, FCRL1, FCRL2, FCRLA, GPM6A, KLHL14, MTRNR2L3, NPIPB5, OSBPL10, PAX5, PCDH9, PHYHD1, POU2AF1, RALGPS2, ZNF888) have shown a novel expression in CVD.

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