Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status.

Using CSF p-tau or t-tau as the predictors, the effect of plasma p-tau181 on tau PET showed a full mediation (53.9% and 30.9%, respectively), as the effect was reduced from highly significant ( P < 0.0001) to reach or near non-significance ( P = 0.20, P = 0.046, respectively; Fig. 3B ).

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