Finally, astrocytes-CDK5i induced a highly significant increase in the number of dendritic protrusions with lengths ranging from 0.5–2 μm ( Figures 7A,E and Supplementary Figures 3A,E ) in both control and glutamate-treated neurons, indicating that astrocytes-CDK5i enhance the formation of dendritic protrusions with functional sizes that possibly represent mature dendritic spines.
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Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions.
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