Stabilin receptors clear LPS and control systemic inflammation.

Alike clearance of LPS in vivo ( Figures 6 A and 6B), the LPS endocytosis by LSEC was studied using 125 I-labeled LPS in vitro ( Figure 6 D), and we found that LPS endocytosis was significantly decreased in LSEC from Stab2 KO and DK mice, and a trend toward significance in Stab1 LSEC compared with WT LSEC ( Figure 6 D); p-value = 0.06.

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Using Ingenuity Pathway Analysis (IPA), we examined the relationship between these differentially expressed and highly significant genes (60 genes) to determine which canonical pathways are involved in LSEC response to LPS.

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