Similar comparisons between untreated and eNAMPT mAb-treated PH rats revealed a total of 60 DEGs (FDR 15%, 33 upregulated, 8 downregulated) with the most highly significant eNAMPT mAb-influenced GO Biologic Processes including “Chronic inflammatory response,” “Lymphocyte and neutrophil chemotaxis,” “Responses to IL-6,” Interferon gamma and TNF,” “Regulation of systemic arterial blood pressure,” and “Chemokine signaling” ( Fig. 4c and d, Supplemental Table 2).
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Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb.
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