Efficacy of Severe Acute Respiratory Syndrome Coronavirus-2 Vaccine in Patients With Thoracic Cancer: A Prospective Study Supporting a Third Dose in Patients With Minimal Serologic Response After Two Vaccine Doses.

Long-term corticosteroid use (aOR = 3.29, 95% CI: 0.96–11.28, with borderline significance p = 0.06), chemotherapy as last treatment (aOR = 3.46, 95% CI: 1.19–10.01, p = 0.02), or single-agent ICI treatment within last 3 months (aOR = 4.18; 95% CI: 1.36–12.82, p = 0.01), were independently associated with antibody titers of at least 50 AU/mL at day 28 .

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However, at 300 AU/mL cutoff, chemotherapy as the last treatment received (aOR = 2.55, 95% CI: 0.90–7.28, p = 0.08), although close to significance, failed to predict a lower probability of seroconversion in patients without COVID-19 history, whereas it did predict such lack of seroconversion in the whole series of patients ( Supplementary Table 1 D ) (aOR = 3.14, 95% CI: 1.08–9.13, p = 0.03).

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