The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression.

PLoS Pathog · 2021 · PMC8594839 · PMID 34735550

Europe PMC DOI

hedged sentence

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highly significantp < 1E-16actually significant

In contrast, highly significant differences were observed between promoter usage in ΔCTCF-HPV18 episomes compared to HPV18 following keratinocyte differentiation (p < 1E-16).

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