Base and Covariate Population Pharmacokinetic Analyses of Dupilumab in Adolescents and Children ≥6 to <12 Years of Age Using Phase 3 Data.

In the model utilizing CL (Table 3 , children ≥6 to <12 years of age), impact of albumin on V c and CL was borderline significant at the backward elimination step; P values based on chi‐square tests were somewhat lower or higher than .005 because of some variability in OFV, with significance depending on the initial parameters.

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Population PK parameters were similar across the age groups in both base and covariate models, with a decreasing trend in V m and k a and an increasing trend in V c with age, where V c was adjusted to the central value of 75 kg.

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