Psilocybin targets a common molecular mechanism for cognitive impairment and increased craving in alcoholism.

Sci Adv · 2021 · PMC8598005 · PMID 34788104

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We observed a highly significant dose but no dose-response effect with similar reduction in relapse for alcohol with both doses of psilocybin as compared to the vehicle (repeated measures ANOVA, dose effect: F [2,28] = 10.08, P < 0.001; lever effect: F [1, 28] = 77.69, P < 0.001; and dose × lever interaction: F [2,28] = 10.40, P < 0.001).

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