Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner.

After correcting for these baseline differences, we found that there was a quasi-significant sex × ACE interaction (F 1,44 = 4.034; P = .051; η p 2 = 0.08) in the first test session that revealed a strongly significant effect of the ACE in the females (F 1,44 = 7.892; P = .007; η p 2 = 0.15) who showed a higher increase in premature responses compared with their performance during baseline.

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