Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer.

J Immunother Cancer · 2021 · PMC8603275 · PMID 34795003

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highly significantno p-value reported

48 49 Intriguingly, we indeed saw that treatment of THP1-reporter cells with high concentrations of TGF-β (like concentrations recovered from OV-patients in UZL-CSI cohort) induced highly significant IFN/ISG (but not NFkB) responses ( figure 3H, I ), thereby suggesting a context-dependent pro-immunogenic role for TGF-β.

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