We found that the tdLNs of ICB-treated liver metastases had significantly fewer total dendritic cells and CD103 − CD11b + dendritic cells, while CD103 + CD11b − dendritic cells showed a decreasing trend ( Fig. 3 E ).
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Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
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