The Evolutionary Landscape of SARS-CoV-2 Variant B.1.1.519 and Its Clinical Impact in Mexico City.

Patients infected with variant B.1.1.519 showed a highly significant adjusted odds ratio (aOR) increase of 1.85 over non-B.1.1.519 patients for developing a severe/critical outcome ( p = 0.000296, 1.33–2.6 95% CI) and a 2.35-fold increase for hospitalization ( p = 0.005, 1.32–4.34 95% CI).

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Although we observed an overall trend of increasing disease seriousness with increasing age groups, infection with B.1.1.519 was still associated with a higher fraction of patients with serious illness and/or death than non-B.1.1.519 infection within each group ( Figure 5 ).

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