Cholesterol-Based Nanovesicles Enhance the In Vitro Cytotoxicity, Ex Vivo Intestinal Absorption, and In Vivo Bioavailability of Flutamide.

Pharmaceutics · 2021 · PMC8623090 · PMID 34834155

Europe PMC DOI

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highly significantp -value < 0.001actually significant

The pharmacokinetic parameters revealed enhancement in oral bioavailability when FLT was delivered as niosomal formulation, confirmed with highly significant AUC 0–∞ with 2 folds increase of FLT-loaded niosomes (741.583 ± 33.557) compared with free FLT suspension (364.536 ± 45.215) that was significant with ( p -value < 0.001).

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