Association of a Total Cholesterol Polygenic Score with Cholesterol Levels and Pathological Biomarkers across the Alzheimer's Disease Spectrum.

Statin free individuals were further stratified on sex ( Figure 1 , right-hand panel, squares and diamonds), revealing a highly significant effect in females; at best, the TC-PGS explained 19.0% of the variance in PREVENT-AD ( p = 6.70 × 10 −9 , p -value cut-off 1 × 10 −10 ) and 13.1% of the variance in ADNI ( p = 9.6 × 10 −4 , p -value cut-off 1 × 10 −7 ).

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