Chemoattraction of Neoplastic Glial Cells with CXCL10, CCL2 and CCL11 as a Paradigm for a Promising Therapeutic Approach for Primary Brain Tumors.

Hence, when looking specifically at peritumoral tumor cell clusters as a surrogate of glial migration and infiltration, the average results between control condition (8 animals) and all chemokine groups were highly significant: CXCL10 (7 animals): 37 vs. 7 ( p < 0.0001), CCL2 (9 animals): 37 vs. 28 ( p = 0.0258), CCL11 (8 animals): 37 vs. 25 ( p = 0.0003) and the combination (7 animals): 37 vs. 24 ( p = 0.0070) ( Figure 3 D). 2.2.2.

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