Whole-genome analysis of Nigerian patients with breast cancer reveals ethnic-driven somatic evolution and distinct genomic subtypes.

The significant enrichment of the early clonal driver GATA3 in the Nigerian group and a positive trend in its recurrence with African ancestry (proportion trend test, P = 0.0035) along with a significantly lower age at diagnosis in patients with tumors carrying GATA3 mutations is likely to be an underlying genomic event associated with young onset breast cancer.

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