extremely significantp < 0.05
For Figures 1 – 7 and Supplementary Figure 4 , data are presented as mean ± SEM, and statistical differences were considered significant, strongly significant, and extremely significant at respective p values of ∗ p < 0.05, ∗∗ p ≤ 0.01, ∗∗∗ p ≤ 0.001, and **** p ≤ 0.0001.