highly significantP -values <0.001
* P -values of 0.001 to 0.05 reflected statistically significant differences; ** P -values of 0.001 to <0.01 were considered highly significant; and *** P -values <0.001 reflected extremely significant differences.
* P -values of 0.001 to 0.05 reflected statistically significant differences; ** P -values of 0.001 to <0.01 were considered highly significant; and *** P -values <0.001 reflected extremely significant differences.