a certain trend toward significanceP =0.0823
Moreover, JAK2 V617F allele burden ≥50% and history of major bleeding had a significant correlation with a worse PFS ( P =0.0225 and P =0.0174, respectively, Online Supplementary Figure S1 ), while WBC count>11x10 9 /L showed a certain trend toward significance ( P =0.0823, Online Supplementary Figure S1 ).