highly significantp < 0.0001
The inhibition potencies towards the wt and the variants had a highly significant correlation ( ρ = 0.9774 and ρ = 0.9581 for N439K and N501Y, respectively, p < 0.0001), with the best-fit X-intercept ranging from 12.38 to 15.89 for the N439K and N501Y, respectively ( Figure 3B, C ).