A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility.

Sci Rep · 2021 · PMC8636478 · PMID 34853329

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may not be significantno p-value reported

However, this Tm difference may not be significant, because the L304Q CSS activity prominently decreases at 35–45 °C below the Tm, while the WT CSS activity remains unchanged by sharp contrast.

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