MicroRNA-activated hydrogel scaffold generated by 3D printing accelerates bone regeneration.

P < 0.05, 0.01, and 0.001 was set to be significant, highly significant, and extremely significant, respectively. 3 Results and discussion 3.1 Characterization of miR-29b/AuNPs nano-delivery system Despite great potential, the full implementation of miRNA therapeutics in the clinic is hampered by inefficient intracellular delivery due to susceptibility to RNase degradation, inefficient membrane penetration, and poor tissue-specific localization [ 14 ].

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