Azithromycin for the prevention of rehospitalisation and death among Kenyan children being discharged from hospital: a double-blind, placebo-controlled, randomised controlled trial.

26 – 28 We observed a slightly higher azithromycin resistance prevalence in E coli isolates from children randomly assigned to the azithromycin group at 3 months but this difference of borderline significance was no longer present at 6 months, consistent with transient increases observed in some mass drug administration trials. 4 – 7 , 29 Our study had high retention (>99%), a well characterised study population, complete adherence to the first dose of study medication, and high adherence to the full 5-day course reported by caregivers.

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