Comparison of TCF4 repeat expansion length in corneal endothelium and leukocytes of patients with Fuchs endothelial corneal dystrophy.

PLoS One · 2021 · PMC8638873 · PMID 34855896

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highly significantno p-value reported

The unique opportunity to collect blood and fellow-eye corneal endothelium (one used for Iso-Seq and the other for primary HCEC line generation) from the same patients, and to then determine that TNR expansion in the TCF4 gene is longer in corneal endothelium DNA compared to those measured in leukocyte DNA is highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.