Time to Onset of Response to Pitolisant for the Treatment of Excessive Daytime Sleepiness and Cataplexy in Patients With Narcolepsy: An Analysis of Randomized, Placebo-Controlled Trials.

The significant difference in ESS score change for the pitolisant group vs the placebo group continued through the end of treatment (with the exception of a marginally significant [ p = 0.05] difference at week 7 in HARMONY 1) and remained statistically significant after a 1-week double-blind placebo washout period in both studies (Fig. 1 ).

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